Understanding why patients with vitiligo rarely develop skin cancers

British Journal of DermatologyVolume 184, Issue 6 p. e204-e204 Plain Language SummaryFree Access Understanding why patients with vitiligo rarely develop skin cancers First published: 06 June 2021 https://doi.org/10.1111/bjd.20108AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have read accept the Wiley Online Library UseShareable LinkUse link a this article your friends colleagues. Learn more.Copy URL Share linkShare onFacebookTwitterLinked InRedditWechat Abstract Linked article: Brahmbhatt et al. Br J Dermatol 2021; 184:1132–1142. Vitiligo is common disorder affecting 0·2–2% world’s population. It occurs because loss cells (melanocytes) responsible for producing melanin (the pigment that gives its characteristic colour) resulting in affected appearing milky white. The presence acts as barrier harmful, cancer-inducing sun’s rays [ultraviolet (UV) radiation]. However, surprisingly, despite melanin, people cancers. This study from India aimed find out reason why. We obtained small samples well unaffected five who had extracted pieces genetic material known microRNAs (miRNAs) them. One miRNA – called miRNA-211 was found be present very low quantities compared skin. could bind another type RNA messenger (mRNA) SIRT1 gene prevent it making sirtuin1 (SIRT1) protein. Lower levels meant less ‘stop signals’, leading an increased expression To understand whether protein protect sun-induced damage, we treated keratinocytes (a cell) chemical activated exposed these UV radiation, mimicking sunlight exposure Exposure radiation showed significant reduction signs DNA damage (cyclobutane pyrimidine dimers) usual levels. Finally, MALAT1, long nonprotein coding molecule, highly expressed skin, unavailable mRNA therefore expression, which protected patient’s Overall, novel molecular basis protection damage. Volume184, Issue6June 2021Pages RelatedInformation